90779-69-4

Manufacturer supply high quality Atosiban Acetate 90779-69-4 with GMP standards We provide high quality Atosiban (CAS 90779-69-4), at a very affordable prices to our customers.

1.What is the Atosiban ?

Atosiban Acetate is an inhibitor of the hormones oxytocin and vasopressin. It is used to halt premature labor（＞18 Years, GA: 24~33 Weeks）. Atosiban is a synthetic peptide oxytocin antagonist.

Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of the vasopressin V1a receptor and of the oxytocin receptor which is found in dramatically increased concentration in the uterine myometrium of pregnant women near term. It competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with atosiban caused pregnancy prolongation for up to 7 days in women with more than 28 weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic action (uterine relaxant) to ritodrine but the former was significantly better tolerated, especially with regards to maternal cardiovascular side effects. In healthy volunteers, plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.

Atosiban is an analogue of oxytocin that is modified at positions 1, 2, 4, and 8. It is a competitive inhibitor of oxytocin binding. Early studies have demonstrated that this drug does decrease and stop uterine contractions. Atosiban is not available for use in the United States.

Atosiban has been used:as an oxytocin receptor antagonistin the calcium mobilization assay for Z factor determination in uterine myometrium (UT-myo cells) and as a therapeutic agent to inhibit preterm laborto inhibit the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice (OxtrPBN)

2.What is the CAS number for Atosiban ?

The CAS number of Atosiban is 90779-69-4.

More information of Atosiban 90779-69-4 are:

3.What is the molecular formula of Atosiban ?

The chemical formula of Atosiban is C43H67N12O38S2 which containing 43 Carbon atoms,67 Hydrogen atoms,12 Nitrogen atoms,38 Oxygen atoms and 2 Sulfur atoms,and the molecular weight, and the molecular weight of Atosiban is 994.19

4.What is Atosiban(90779-69-4)used for?

Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of the vasopressin V1a receptor and of the oxytocin receptor which is found in dramatically increased concentration in the uterine myometrium of pregnant women near term. It competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with atosiban caused pregnancy prolongation for up to 7 days in women with more than 28 weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic action (uterine relaxant) to ritodrine but the former was significantly better tolerated, especially with regards to maternal cardiovascular side effects. In healthy volunteers, plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.

InChI:InChI=1/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36?/m0/s1

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5.Manufacturer supply high quality Atosiban Acetate 90779-69-4 with GMP standards

Harbin Jixianglong Biotech Co., Ltd. is a quality supplier of Atosiban. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Atosiban 90779-69-4.